Abnormal testis morphology Sertoli cell hyperplasia 2023-05-17T23:10:37Z Abnormal increase in the number of Sertoli cells in the testis. Sertoli cells are present in the seminiferous tubules of the testes, comprising one of the two types of cells in the germinal epithelium, the other being of spermatogonia lineage. Sertoli cells are one of the most important cells necessary for sperm production in males. They are often identifiable as big, tightly linked cells near the basolateral portion of the seminiferous tubule.