Abnormal epidermis stratum granulosum morphology Abnormal keratinocyte morphology Large keratohyaline granules 2023-07-09T14:05:51Z The chief function of keratohyaline granules seems to be cross-linking of keratin filaments which creates the tight barrier that is the epidermis. Abnormally large keratohyalin granules (KHG). KHG are typically present in the stratum granulosum of the epidermal layer of the skin (and epithelium of the mucosae). KHG are protein structures found in the keratinocytes of the stratum granulosum.