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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
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    <!-- http://purl.obolibrary.org/obo/BFO_0000051 -->

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        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label>has part</rdfs:label>
        <rdfs:label xml:lang="en">has part</rdfs:label>
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        <rdfs:label xml:lang="en">characteristic of</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/HP_0000240 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0000240">
        <rdfs:label>Abnormality of skull size</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/HP_0040195 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0040195">
        <rdfs:label>Decreased head circumference</rdfs:label>
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        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0000240"/>
        <dcterms:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-09-24T14:57:07Z</dcterms:date>
        <oboInOwl:hasDbXref>SNOMEDCT_US:271611007</oboInOwl:hasDbXref>
        <rdfs:comment>Although HC measures skull size, it typically also reflects overall brain volume and has been described as a widely used proxy of neural growth and brain size. Brain size outside of normal values is an important risk factor for cognitive and motor delay. Microcephaly at birth has been termed primary microcephaly and that acquired after birth is secondary microcephaly.</rdfs:comment>
        <oboInOwl:hasDbXref>UMLS:C0424688</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean.</ns4:IAO_0000115>
        <oboInOwl:hasExactSynonym>Decreased head circumference</oboInOwl:hasExactSynonym>
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    <!-- http://purl.obolibrary.org/obo/PATO_0000460 -->

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        <rdfs:label>abnormal</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/PATO_0001899 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001899">
        <rdfs:label>decreased circumference</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/UBERON_0000033 -->

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        <rdfs:label>head</rdfs:label>
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