has part has part characteristic of inheres in has modifier neural tube closure Neural tube defect UMLS:C0027794 Abnormality of neural tube closure A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine. NTD SNOMEDCT_US:253098009 Abnormal neural tube morphology abnormal process quality