Ulcerative colitis 2010-08-10T09:25:44Z SNOMEDCT_US:64766004 UMLS:C0009324 HP:0100279 Colitis ulcerosa A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon. Chronic colitis