Thickened skin Scleroderma 2010-08-10T04:14:42Z HP:0007426 HP:0100324 A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin. HP:0001594 A chronic autoimmune phenomenon characterised by fibrosis (or hardening), vascular alterations, and autoantibodies. Sclerosis of the skin occurs in association with disorders as diverse as mixed connective tissue disease and systemic sclerosis. This term is intended to represent the phenotypic feature scleroderma rather than a particular disease. Pseudoscleroderma Progressive systemic scleroderma