Localized skin lesion Skin nodule 2010-06-18T01:48:50Z UMLS:C0037287 HP:0200036 SNOMEDCT_US:95319004 Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat. A nodule is a palpable, solid, round lesion in the deep skin or subcuteaneous tissues that is larger and deeper than a papule. Nodules are solid circumscribed masses. A common definition is that a skin nodule has a diameter of more than 5 mm in infants and more than 10 mm in older children. Growth of abnormal tissue on or under the skin