Autoimmune antibody positivity Anti-SOX1 antibody 2021-06-13T12:02:48Z Anti-Sry-like high mobility group box (SOX) 1 antibody The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SOX1. Anti-SOX1 antibodies, also known as antiglial nuclear antibody (AGNA), are specifically found in paraneoplastic neurological disorders. Since SOX1 is expressed in neuronal precursor cells in the developing central nervous system, it has been used as an early marker of neural stem cells.