Opportunistic fungal infection Unusual vaginal infection Unusual fungal vaginal infection Increased susceptibility to vulvovaginal candidiasis, as manifested by recurrent or severe infection of the vagina or vulvovaginal area caused by Candida species. Predominantly caused by Candida albicans, with Candida glabrata in azole-resistant cases. Unusual fungal vaginal infection can be observed in individuals with T-cell deficiencies, IL-17 pathway defects, and chronic mucocutaneous candidiasis. Recurrent vulvovaginal candidiasis has been documented in patients with IL-12Rbeta1 deficiency and in patients with impaired T-lymphocyte proliferation in response to Candida antigen.