Tegumentary leishmaniasis susceptibility Unusual parasitic skin infection Unusual cutaneous leishmaniasis Unusual cutaneous leishmaniasis Unusual mucocutaneous leishmaniasis Unusual susceptibility to cutaneous Leishmania infection Infection of the skin and subcutaneous tissue by Leishmania species, as manifested by cutaneous or mucocutaneous leishmaniasis occurring in the context of unusual susceptibility to infection. Cutaneous leishmaniasis presents with chronic, non-healing ulcerative skin lesions. In the context of inborn errors of immunity, susceptibility to Leishmania species is associated with defects in the IL-12/IFN-gamma axis, including Mendelian susceptibility to mycobacterial disease (MSMD) gene defects.