Opportunistic viral infection Chronic warts Chronic warts are characteristic of T-cell deficiencies (DOCK8, GATA2), WHIM syndrome (CXCR4), and epidermodysplasia verruciformis (EVER1, EVER2, CIB1). Persistent warts Increased susceptibility to chronic or persistent human papillomavirus (HPV) infection causing warts that fail to clear over an extended period or recur after treatment that occurs in the context of unusual susceptibility to infection.