Abnormal peripheral nervous system morphology Metachromatic intraneuronal lipid deposits 2023-12-30T23:26:21Z A type of metachromasia localized to a peripheral nerve. Metachromasia may be defined as the staining of tissue or tissue components such that the color of the tissue-bound dye complex differs significantly from the color of the original dye complex to give a marked contrast in color. For instance in metachromatic leukodystrophy, bloated Schwann cells, containing granularmetachromatic storage material May display a characteristic yellow green dichroism under crossed polarised light. HP:6001030 In metachromatic leukodystrophy, galactosyl sulfatide (cerebroside sulfate) accumulates in the white matter of the CNS and in the peripheral nerves. Galactosyl sulfatide, and to a lesser extent lactosyl sulfatide, also accumulate within the kidney, gallbladder, and certain other visceral organs and are excreted in excessive amounts in the urine. In histologic preparations, they form spherical granular masses that stain metachromatically (i.e., with a color different from that of the dye solution). See Figure 2 of PMID:16291896. Peripheral nerve metachromasia