Abnormal sperm head morphology Ruffled acrosome 2024-03-08T14:46:39Z An irregular wavy appearance of sperm acrosomes. The human acrosome and the acrosome reaction are important for human fertilization. Acrosome-intact sperm bind to the surface of the zona pellucida, where the physiological acrosome reaction is thought to be induced by zona pellucida glycoproteins. The proportion of sperm that react with acrosomes on the surface of the zona pellucida (the zona pellucida-induced acrosome reaction) is strongly correlated with the proportion of oocytes penetrated by sperm during in vitro fertilization.