Abnormal enzyme activity in cultured fibroblasts Reduced Inositol polyphosphate 5-phosphatase OCRL-1 activity in cultured fibroblasts 2024-03-29T17:23:48Z Concentration or activity of inositol polyphosphate 5-phosphatase OCRL-1 as measured in cultured fibroblasts is below the limits of normal. This enzyme has phosphoinositide 5-phosphatase (EC 3.1.3.36) activity.