Autoimmune antibody positivity Anti-von Willebrand factor antibody positivity 2024-04-01T08:13:26Z This feature is usually seen in the context of Von Willebrand disease (VWD), the most common inherited bleeding disorder. VWD is caused by deficiency or dysfunction of the multimeric glycoprotein, von Willebrand factor (VWF), and is clinically characterized by excessive mucocutaneous bleeding as well as musculoskeletal bleeding in type 3 VWD, the most severe form. Treatment options include infusion of concentrates of VWF, which in some patients leads to the production of alloantikbodies. The presence of autoantibodies in the serum that react to von Willebrand factor (VWF).