Abnormal hepatic iron concentration Hepatic reticuloendothelial system cell iron deposition 2024-05-08T18:55:23Z Abnormal accumulation of iron in reticuloendothelial cells of the liver. This feature can be appreciated on liver biopsy by Perls iron stain for granular iron deposition, based on agreement that only discernible hemosiderin granules represent significant iron deposition.