Abnormality of the hepatic vasculature Terminal hepatic lobular vascular occlusion 2024-05-09T07:03:22Z Hepatic veno-occlusive disease Hepatic veno-occlusive disease (VOD) may present with fragmented red blood cells, fibrinogen, and Factor VIII/von Willebrand factor can be demonstrated in the subendothelial space of central veins and perivenular zones of hepatic acini. In the later stages, sinusoidal and venous lumen become obliterated by typeI, III, and IV collagen accompanied by an increase in the stellate cells that line the sinusoids. In some cases, fibrous bridges between central venules are observed. A type of Hepatic venous outflow obstruction characterized by fibrous concentric narrowing of zone 3 terminal hepatic venules, centrilobular hepatocyte necrosis, and sinusoidal congestion, accomapnied by necrosis of pericentral hepatocytes, and narrowing and eventual fibrosis of central veins. Hepatic sinusoidal obstruction syndrome