Reticulated skin pigmentation Flexural reticulate hyperpigmentation 2024-05-21T09:58:54Z Reticulate hyperpigmentation of the flexures Hyperpigmented macules with a reticulate (net-like) pattern involving the neck, axillae, groins, and other flexures like the inframammary folds in females. Histopathology shows orthokeratosis or hyperkeratosis, thinning of the suprapapillary epithelium, elongation of the rete ridges, hyperpigmentation of the basal layer, and follicular cysts. A perivascular lymphohistiocytic infiltrate can be observed in the papillary dermis. Reticular pigmented anomaly of the flexures