Abnormal circulating erythropoietin concentration Inappropriate normal or low erythropoietin 2024-07-12T10:19:08Z Erythropoietin is produced and released into the blood by the kidneys in response to hypoxemia, and would normally be expected to increase with decreasing hemoglobin levels. This term applies if the increase fails to occur, as may be seen in conditions including chronic kidney disease.