Abnormal lymph node morphology Mediastinal lymph node calcification 2024-07-12T10:19:08Z Abnormal deposition of calcium in mediastinal lymph nodes. Calcified mediastinal lymph nodes Lymph node calcifications most often result from prior granulomatous infections, especially tuberculosis and histoplasmosis. Other, less common, causes are sarcoidosis, silicosis, amyloidosis, and calcifications secondary to the treatment of lymphomas (radiation therapy or chemotherapy).