Abnormal epidermal morphology Spongiosis 2025-01-31T09:45:36Z Comment: Spongiosis is present in all diseases manifesting clinically as eczema; however, there are diseases with spongiosis that do not belong to the eczema spectrum, e.g., pityriasis rosea, erysipelas or tinea. . Spongiotic dermatoses include a very large list of disorders which are best grouped under neutrophilic, eosinophilic, miliarial, follicular and pityriasiform forms of spongiosis. Spongiosis refers to the increased intercellular edema in the epidermis resulting in the pulling away of the keratinocytes from their surrounding desmosomes. Histologically, the spongiotic tissue reaction pattern involves the accumulation of fluid in the intercellular spaces of the epidermis, making the desmosomes junctions more easy to appreciate. Parakeratosis forms above the areas of spongiosis. The foci of spongiosis can be microscopic to grossly identifiable clinically with vesicles or bullae.