part of part of has part has part characteristic of inheres in has modifier Abnormal circulating protein concentration Decreased circulating progranulin concentration 2025-03-01T11:10:50Z Reduced progranulin level Decreased progranulin concentration Decreased circulating progranulin concentration Decreased progranulin level Reduced progranulin level in blood The concentration of progranulin in the blood circulation is below the lower limit of normal. Progranulin, a secreted glycoprotein, maintains cerebrocortical viability. It has been identified as an important factor controlling neural function while also suppressing neuroinflammation and playing roles in neuronal lysosome function. Loss of one allele of GRN, the gene encoding progranulin, leads to the development of frontotemporal dementia, and loss of both alleles leads to the development of neuronal ceroid lipofuscinosis. Decreased progranulin level in blood Reduced progranulin concentration abnormal decreased amount progranulin (human) blood