Invasive fungal infection Unusual Candida infection Severe Candida infection 2025-08-10T11:09:56Z Increased susceptibility to Candida infections as manifested by a severe or invasive infection with Candida. Severe manifestations include invasive candidiasis with hematogenous spread (candidaemia), hepatosplenic candidiasis, renal candidiasis, Candida endophthalmitis, and Candida endocarditis. Invasive candidiasis Hepatosplenic candidiasis Candida species are colonizers of the human skin and gastrointestinal (GI) tract, existing as part of the microbiome in many healthy individuals. The pathophysiology of disseminated candidiasis in immunocompromised patients is poorly understood but thought to be related to chemotherapy-induced mucositis and profound neutropenia. This allows for Candida species to enter the bloodstream where the organisms can translocate into the portal venous system and seed to the liver and spleen, which explains why the lesions are primarily seen in these two organs. Renal, pulmonary, and other organ involvement have also been documented but not as common. Disseminated candidiasis