Abnormal retinal pigmentation Pigment epithelium detachment 2025-08-31T17:29:42Z Pigment epithelial detachment (PED) is a common feature in patients with exudative age-related macular degeneration. The prevalence of a PED has been reported to be 10-64% in eyes with polypoidal choroidal vasculopathy, and 10-22% in eyes with typical exudative AMD with choroidal neovascularization. The natural course is characterised by enlargement of the PED with consecutive regression and atrophy of the RPE and outer retina in avascular PEDs or formation of a disciform scar in vascularized PEDs. Separation of the retinal pigment epithelium (RPE) from the underlying Bruch membrane.