Increased total leukocyte count Hyperleukocytosis 2025-11-19T09:34:39Z Hyperleukocytosis can be observed in conditions such as acute myeloid leukemia, which is characterized by the clonal proliferation of hematopoietic stem cells. Hyperleukocytosis is regarded as a hematological emergeny and can lead to complications such as leukostasis, disseminated intravascular coagulation, and tumor lysis syndrome. Hyperleukocytosis is commonly defined as a white blood cell (WBC) count of greater than 100,000 luekocytes per microliter.