develops from developmentally induced by has potential to develop into metanephros ureteric bud mesonephric duct mesenchyme metanephric mesenchyme metanephric blastema metanephrogenic mesenchyme EHDAA2:0004062 EHDAA:5915 One of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]. SCTID:361529008 VHOG:0000540 EHDAA:5021 Genes: The positional specification of the metanephrogenic mesenchyme is negatively regulated by Foxc1 and Foxc2. Next the permanent kidney forming metanephrogenic mesenchyme is specified by Hox11 genes. The competence to respond to ureteric bud inducers is regulated by WT1. GDNF secretion restricted to posterior region by Robo2 and Sprouty1. The receptors for GDNF are synthesized in the nephric ducts and later in ureteric buds [ISBN:9780878932504 "Developmental Biology"] EMAPA:17375 UBERON:0003220 Wikipedia:Metanephric_blastema metanephros associated mesenchyme EHDAA:4041 metanephric mesoderm kidney mesenchyme mesoderm-derived structure embryonic tissue presumptive structure