part of part of capable of regulation of blood volume by renin-angiotensin endocrine system organ system subdivision renin-angiotensin system MESH:D012084 renin angiotensin aldosterone system FMA:74787 renin angiotensin system renin-angiotensin system A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex. UBERON:0018229 renin-angiotensin-aldosterone system