material entity material entity pathological anatomical structure creation date: 2009-07-13T02:14:05Z An anatomical structure (FMA) is pathological whenever (1) it has come into being as a result of changes in some pre-existing canonical anatomical structure, (2) through processes other than the expression of the normal complement of genes of an organism of the given type, and (3) is predisposed to have health-related consequences for the organism in question manifested by symptoms and signs. http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf Albert Goldfain