ICE IEM for integration recombination module component Meng LIU (Mia), Oliver He https://academic.oup.com/nar/article/47/D1/D660/5165266 The integration and excision module refers to those genes and sequence within the ICE responsible for the integration and excision of the element from the host chromosome, including genes encoding the integrase and or recombination directionality factor (also known as excisionase, which influences the direction of recombination mediated by the integrase to favor excision). ICE integration and excision module