has role tyrosine recombinase Meng LIU (Mia), Oliver He tyrosine recombinase is the most common integrase seen in T4SS-type ICEs https://en.wikipedia.org/wiki/Site-specific_recombination One family of recombinases based on amino acid sequence homology and mechanistic relatedness. Tyrosine is the conserved nucleophilic amino acid residue that tyrosine recombinases use to attack the DNA and which becomes covalently linked to it during strand exchange. integrase role protein