document Institutional Review Board Approval Regulation or Law Study Site specific document containing the determination of the Institutional Review Board (IRB) or Independent Ethics Committee (IEC) that the clinical study with human subject participation has been reviewed and may be conducted at a particular study site within the constraints set forth by the IRB and other institutional and federal requirements. [NCI] Institutional Review Board Approval A document containing the determination of the Institutional Review Board (IRB) that the clinical study with human subject participation has been reviewed and may be conducted at a particular study site within the constraints set forth by the IRB and other institutional and federal requirements. The regulations require that an IRB conduct continuing review of research at intervals appropriate to the degree of risk, but not less than once a year. IRB/IEC Submission Approval approval (in relation to Institutional Review Boards) CareLex Institutional Review Board Approval C2346499 CDISC-GLOSS The affirmative decision of the IRB that the clinical trial has been reviewed and may be conducted at the institution site within the constraints set forth by the IRB, the institution, good clinical practice (GCP), and the applicable regulatory requirements. [ICH E6] Institutional_Review_Board_Approval IRB-IEC Approv IRB Approval IRB-IEC Approval C70800 Institutional Review Board Independent Ethics Committee Approval