aminoglycoside gentamicin YH,YL Gentamicin is more active in vitro against Brucella species than streptomycin and, when administered as a single daily dose, is associated with few adverse side-effects. Although gentamicin, in a dose of 5mg/kg/day intravenously or intramuscularly, administered for 7 to 10 days in combination with doxycycline administered for six weeks, yielded good results in one study, experience with this regimen is too limited to justify its use over doxycycline plus streptomycin. Unfortunately, no direct study comparing the results of doxycycline plus streptomycin versus doxycycline plus gentamicin has yet been published. Until additional experience is gained using gentamicin in place of streptomycin, the optimal dose and duration of therapy remain unknown. (http://www.who.int/csr/resources/publications/Brucellosis.pdf p37)