has_part has part has_part has disposition at some time attenuated disposition B. suis virB5 mutant B. suis 1330 virB5 mutant PMID: 10510235 A mutant of strain Brucella suis 1330 that lacks an intact gene virB5. YH UniProtKB accession: Q9RPY0 NCBIGene: 1164502 The gene virB5 from the strain Brucella suis 1330 is a virulence gene. Information about the mutated molecule: MUTATION: A comparison of the VirB8 and VirB5 contents after induction of the B suis wild type and of virB5 and virB12 mutants further confirmed that the virB5 and virB12 genes belong to the same operon [Ref6467:O'Callaghan et al., 1999]. Smooth strains of Brucella unable to replicate (ie, killed B suis or the avirulent mutant B suis virB5) exhibit delayed phagosome-lysosome fusion [Ref6467:O'Callaghan et al., 1999]. Polar mutations in the operon upstream of virB5 exert a greater effect on the expression of virB5 than they do on the expression of the downstream gene virB12. It indicates that in B abortus , regulatory elements other than the virB promoter may influence VirB12 protein levels [Ref6467:O'Callaghan et al., 1999]. Four independent mutants in virB5, virB9 or virB10 were highly attenuated in an in vitro infection model with human macrophages [Ref6467:O'Callaghan et al., 1999]. BRA0065 type IV secretion system protein VirB5