has_part has part has_part has disposition at some time B. suis glnD mutant attenuated disposition B. suis 1330 glnD mutant A mutant of strain Brucella suis 1330 that lacks an intact gene glnD. UniProtKB accession: Q8G312 PMID: 10678941 NCBIGene: 1165801 Information about the mutated molecule: FUNCTION: Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein (By similarity)(Swiss-Prot: Q8G312). CATALYTIC ACTIVITY: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII](Swiss-Prot: Q8G312). SIMILARITY: Belongs to the glnD family(Swiss-Prot: Q8G312). MUTATION: glnD encodes for a uridylyl transferase which is the primary sensor of nitrogen. The glnD mutant via signature-tagged transposon mutagenesis is attenuated in THP1 macrophages and HeLa cells. It supports the hypothesis that the concentration of glutamine in host cells is critical for the intracellular survival of Brucella [Ref6484:Foulongne et al., 2000]. The gene glnD from the strain Brucella suis 1330 is a virulence gene. YH BR0144 PII uridylyl-transferase