has_part has part has_part has disposition at some time attenuated disposition B. abortus uvrA mutant B. suis 1330 uvrA mutant UniProtKB accession: Q8G0I9 YH PMID: 16816190 NCBIGene: 1166780 Information about the mutated molecule: FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate (By similarity)(Swiss-Prot: Q8G0I9). SUBUNIT: Forms a heterotetramer with uvrB during the search for lesions (By similarity)(Swiss-Prot: Q8G0I9). SUBCELLULAR LOCATION: Cytoplasm (By similarity)(Swiss-Prot: Q8G0I9). SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily(Swiss-Prot: Q8G0I9). SIMILARITY: Contains 2 ABC transporter domains(Swiss-Prot: Q8G0I9). MUTATION: B. abortus urvA and recA mutants exhibited greater sensitivity than the wild-type strain. Mutant strains carrying inactivated uvrA genes are typically less sensitive than recA mutants because there is only the loss of the nucleotide excision repair system, just one subset of the larger repair networks. However, it was found that the recA mutant conferred only a modest sensitivity to UV, substantially less sensitive than the uvrA mutant. High basal recA expression was observed in the uvrA repair mutant. The B abortus recA mutant exhibited a nearly fourfold decline in survival to murine peritoneal macrophages but nominal sensitivity for the uvrA and radA repair mutants [Ref6493:Roux et al., 2006]. The gene uvrA from the strain Brucella suis 1330 is a virulence gene. A mutant of strain Brucella suis 1330 that lacks an intact gene uvrA. uvrA excinuclease ABC subunit A