has_part has part has_part has disposition at some time B. suis uppS mutant attenuated disposition B. suis 1330 uppS mutant NCBIGene: 1166834 Information about the mutated molecule: FUNCTION: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (By similarity)(Swiss-Prot: Q8G0D9). CATALYTIC ACTIVITY: Di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans,poly-cis-undecaprenyl diphosphate(Swiss-Prot: Q8G0D9). COFACTOR: Magnesium (By similarity)(Swiss-Prot: Q8G0D9). SUBUNIT: Homodimer (By similarity)(Swiss-Prot: Q8G0D9). SIMILARITY: Belongs to the UPP synthetase family(Swiss-Prot: Q8G0D9). MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis uppS gene is required for intracellular multiplication in human macrophage THP-1 cells [Ref412:Kohler et al., 2002]. YH A mutant of strain Brucella suis 1330 that lacks an intact gene uppS. UniProtKB accession: Q8G0D9 The gene uppS from the strain Brucella suis 1330 is a virulence gene. PMID: 12438693 uppS undecaprenyl diphosphate synthase