has_part has part has_part has disposition at some time attenuated disposition B. suis hisF mutant B. suis 1330 hisF mutant Information about the mutated molecule: FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit (By similarity)(Swiss-Prot: Q8FY07). CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O(Swiss-Prot: Q8FY07). PATHWAY: Amino-acid biosynthesis YH NCBIGene: 1167788 The gene hisF from the strain Brucella suis 1330 is a virulence gene. A mutant of strain Brucella suis 1330 that lacks an intact gene hisF. PMID: L-histidine biosynthesis UniProtKB accession: Q8FY07 hisF imidazole glycerol phosphate synthase subunit HisF