has_part has part has_part has disposition at some time attenuated disposition B. abortus purH mutant B. melitensis 16M purH mutant Information about the mutated molecule: CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(Swiss-Prot: P67540). CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(Swiss-Prot: P67540). PATHWAY: Nucleotide biosynthesis PMID: IMP biosynthesis YH A mutant of strain Brucella melitensis bv. 1 str. 16M that lacks an intact gene purH. The gene purH from the strain Brucella melitensis bv. 1 str. 16M is a virulence gene. NCBIGene: 1195945 UniProtKB accession: P67539 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase