has_part has part has_part has disposition at some time B. abortus purE mutant attenuated disposition B. melitensis 16M purE mutant PMID: IMP biosynthesis YH Information about the mutated molecule: FUNCTION: This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition (By similarity)(Swiss-Prot: Q8FYW3). CATALYTIC ACTIVITY: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)(Swiss-Prot: Q8FYW3). PATHWAY: Nucleotide biosynthesis The gene purE from the strain Brucella melitensis bv. 1 str. 16M is a virulence gene. NCBIGene: 1196007 UniProtKB accession: P52558 A mutant of strain Brucella melitensis bv. 1 str. 16M that lacks an intact gene purE. BMEI0296 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT