has_part has part has_part has disposition at some time B. suis uppS mutant attenuated disposition B. melitensis 16M uppS mutant YH Information about the mutated molecule: FUNCTION: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (By similarity)(Swiss-Prot: Q8G0D9). CATALYTIC ACTIVITY: Di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans,poly-cis-undecaprenyl diphosphate(Swiss-Prot: Q8G0D9). COFACTOR: Magnesium (By similarity)(Swiss-Prot: Q8G0D9). SUBUNIT: Homodimer (By similarity)(Swiss-Prot: Q8G0D9). SIMILARITY: Belongs to the UPP synthetase family(Swiss-Prot: Q8G0D9). MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis uppS gene is required for intracellular multiplication in human macrophage THP-1 cells [Ref412:Kohler et al., 2002]. NCBIGene: 1196538 UniProtKB accession: Q8YHH3 The gene uppS from the strain Brucella melitensis bv. 1 str. 16M is a virulence gene. PMID: 12438693 A mutant of strain Brucella melitensis bv. 1 str. 16M that lacks an intact gene uppS. BMEI0827 UNDECAPRENYL PYROPHOSPHATE SYNTHETASE