has_part has part has_part has disposition at some time attenuated disposition B. suis hisF mutant B. melitensis 16M hisF mutant PMID: L-histidine biosynthesis YH A mutant of strain Brucella melitensis bv. 1 str. 16M that lacks an intact gene hisF. UniProtKB accession: Q8YE37 Information about the mutated molecule: FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit (By similarity)(Swiss-Prot: Q8FY07). CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O(Swiss-Prot: Q8FY07). PATHWAY: Amino-acid biosynthesis NCBIGene: 1197752 The gene hisF from the strain Brucella melitensis bv. 1 str. 16M is a virulence gene. BMEI2041 imidazole glycerol phosphate synthase subunit HisF