has_part has part has_part has disposition at some time attenuated disposition Brucella omp10 mutant B. melitensis 16M omp10 mutant The gene omp10 from the strain Brucella melitensis bv. 1 str. 16M is a virulence gene. Information about the mutated molecule: SUBCELLULAR LOCATION: Outer membrane UniProtKB accession: P0A3N8 PMID: lipid-anchor(Swiss-Prot: P0A3N9). MISCELLANEOUS: Elicits an immune response in B.melitensis-infected sheep but not in B.abortus-infected cattle(Swiss-Prot: P0A3N9). SIMILARITY: Belongs to the rhizobiaceae omp10 lipoprotein family(Swiss-Prot: P0A3N9). MUTATION: Omp10 is an immunoreactive outer membrane lipoprotein. The omp10 mutant was dramatically attenuated for survival in mice and was defective for growth in minimal medium but was not impaired in intracellular growth in vitro, nor does it display clear modification of the outer membrane properties [Ref6473:Tibor et al., 2002]. A mutant of strain Brucella melitensis bv. 1 str. 16M that lacks an intact gene omp10. NCBIGene: 1197788 YH BMEII0017 OUTER MEMBRANE LIPOPROTEIN