has_part has part has_part has disposition at some time attenuated disposition B. suis eryB mutant B. melitensis 16M eryB mutant PMID: 10708387, 16177356 UniProtKB accession: Q8YCU9 YH The gene eryB from the strain Brucella melitensis bv. 1 str. 16M is a virulence gene. Information about the mutated molecule: MUTATION: EryB is an erythritol phosphate dehydrogenase. The vaccine strain B abortus B19 is the only known B abortus isolate whose growth is inhibited by erythritol. The B abortus B19 strain is an eryCD double mutant. The defect in B19 was complemented in trans by plasmids containing the complete ery region and by plasmids with Tn1725 insertions in eryA, eryB and eryD. Plasmids with Tn1725 insertions in eryC were the only ones that failed to complement the Ery phenotype of B19 [Ref6483:Sangari et al., 2000]. The B. suis eryB mutant by Tn5 transposon mutagenesis was attenuated in the human macrophage -like THP-1 cells. This mutant is sensitive to erythritol and mimics the erythritol sensitive response of the B19 strain [Ref6551:Burkhardt et al., 2005]. A mutant of strain Brucella melitensis bv. 1 str. 16M that lacks an intact gene eryB. NCBIGene: 1198201 BMEII0429 glycerol-3-phosphate dehydrogenase