has_part has part has_part has disposition at some time attenuated disposition B. suis dut mutant B. abortus 2308 dut mutant A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene dut. UniProtKB accession: Q2YRG4 Information about the mutated molecule: FUNCTION: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)(Swiss-Prot: P64005). CATALYTIC ACTIVITY: dUTP + H(2)O = dUMP + diphosphate(Swiss-Prot: P64005). PATHWAY: De novo synthesis of thymidylate(Swiss-Prot: P64005). SIMILARITY: Belongs toMUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis dut gene is required for intracellular multiplication in human macrophage THP-1 cells [Ref412:Kohler et al., 2002]. the dUTPase family(Swiss-Prot: P64005). PMID: 12438693 The gene dut from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. YH NCBIGene: 3788687 dut deoxyuridine 5'-triphosphate nucleotidohydrolase