has_part has part has_part has disposition at some time B. suis hisD mutant attenuated disposition B. abortus 2308 hisD mutant A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene hisD. Information about the mutated molecule: FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity)(Swiss-Prot: Q8G2R2). CATALYTIC ACTIVITY: L-histidinol + 2 NAD(+) = L-histidine + 2 NADH(Swiss-Prot: Q8G2R2). COFACTOR: Binds 1 zinc ion per subunit (By similarity)(Swiss-Prot: Q8G2R2). PATHWAY: Amino-acid biosynthesis YH NCBIGene: 3788752 The gene hisD from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. PMID: L-histidine biosynthesis UniProtKB accession: Q2YPB8 hisD histidinol dehydrogenase