has_part has part has_part has disposition at some time attenuated disposition B. suis hisF mutant B. abortus 2308 hisF mutant UniProtKB accession: Q2YQY8 Information about the mutated molecule: FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit (By similarity)(Swiss-Prot: Q8FY07). CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O(Swiss-Prot: Q8FY07). PATHWAY: Amino-acid biosynthesis A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene hisF. YH PMID: L-histidine biosynthesis NCBIGene: 3788754 The gene hisF from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. hisF imidazole glycerol phosphate synthase subunit HisF