has_part has part has_part has disposition at some time attenuated disposition B. suis ntrC mutant B. abortus 2308 ntrC mutant UniProtKB accession: Q2YPW4 Information about the mutated molecule: MUTATION: ntrC encodes for a response regulator subfamily (NtrC). A B suis ntrC isogenic mutant was constructed which showed no significant differences in growth rates compared to the wild-type strain when grown at different temperatures in vitro. However, the mutant exhibited a reduction in metabolic activity in the presence of many amino acids. The mutation did not affect survival or multiplication of B suis in macrophages, but during the initial stages of infection in the murine brucellosis model, the ntrC mutant showed a reduced ability to multiply rapidly in splenic tissue [Ref6496:Dorrell et al., 1999]. NCBIGene: 3788817 YH PMID: 10373105 A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene ntrC. The gene ntrC from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. ntrC CbxX/CfqX superfamily:Response regulator receiver:Sigma-54 factor interaction domain:Helix-turn-helix, Fis-type:AAA ATPase