has_part has part has_part has disposition at some time attenuated disposition Brucella omp19 mutant B. abortus 2308 omp19 mutant PMID: lipid-anchor(Swiss-Prot: P0A3P2). MISCELLANEOUS: Elicits an immune response in humans, mice, sheep and goats infected with B.melitensis or B.abortus, but not in B.abortus-infected cattle(Swiss-Prot: P0A3P2). SIMILARITY: Belongs to the rhizobiaceae omp19 lipoprotein family(Swiss-Prot: P0A3P2). MUTATION: Omp19 is an immunoreactive outer membrane lipoprotein. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B abortus [Ref6473:Tibor et al., 2002]. The gene omp19 from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. UniProtKB accession: Q2YLR6 A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene omp19. Information about the mutated molecule: SUBCELLULAR LOCATION: Outer membrane YH NCBIGene: 3788831 omp19 lipoprotein Omp19