has_part has part has_part has disposition at some time attenuated disposition B. abortus pgm mutant B. abortus 2308 pgm mutant Information about the mutated molecule: MUTATION: Brucella pgm encodes the phosphoglucomutase. The B. abortus pgm mutant (B2211) lacks the O antigen. However, the core region of the mutant LPS migrated in Tricine-PAGE electrophoresis in a position that was indistinguishable from that of the wild type core. Although the exponential intracellular replication of the pgm mutant was delayed by approximately 20 h with respect to that of the wild type, the high number of recoverable bacteria at 48 h postinfection indicates that mutant strain B2211 replicates inside HeLa host cells [Ref6486:Ugalde et al., 2000]. B abortus phosphoglucomutase (pgm) insertional mutants were attenuated in vivo but not in vitro [Ref6486:Ugalde et al., 2000]. A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene pgm. YH UniProtKB accession: Q2YPS4 NCBIGene: 3788847 The gene pgm from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. PMID: 10992476 pgm phosphoglucomutase