has_part has part has_part has disposition at some time attenuated disposition B. abortus pheA mutant B. abortus 2308 pheA mutant YH NCBIGene: 3788850 A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene pheA. UniProtKB accession: Q2YPM5 Information about the mutated molecule: MUTATION: The product of pheA gene is specifically dedicated to the biosynthesis of phenylalanine. The B. abortus pheA mutant with mini-Tn5 disruption displays nutritional defects in vitro. Experimental findings with the B abortus ilvD, trpB, and pheA mutants suggest that tryptophan and phenylalanine are available to the brucellae in their intracellular niche but that other amino acids (eg, leucine, isoleucine, or valine) are not. The pheA::miniTn5 mutant displayed attenuation in macrophages but not in mice [Ref6485:Alcantara et al., 2004]. PMID: 15271960 The gene pheA from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. pheA prephenate dehydratase